Endothelial cell function in diabetic microangiopathy
نویسندگان
چکیده
منابع مشابه
Introduction Diabetic microangiopathy
As a constant evolution in microangiopathy is obviously one of the important features of Diabetes mellitus, different paraclinical approaches have been proposed, and their aspects and results have been presented at this symposium. Several techniques are now available to investigate the anatomical changes of capillaries, such as Vital Capillary Microscopy (Nikolaos Pangratis) allowing to observe...
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Hyperglycaemia occurring in diabetes is responsible for accelerated arterial remodeling and atherosclerosis, affecting the macro- and the microcirculatory system. Vessel injury is mainly related to deregulation of glucose homeostasis and insulin/insulin-precursors production, generation of advanced glycation end-products, reduction in nitric oxide synthesis, and oxidative and reductive stress. ...
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In a pair of 19-year-old monozygotic twin girls, one developed insulin-dependent, ketosis-prone diabetes at the age of three and has required insulin for the past 16 years. Her identical twin has maintained normal oral and intravenous glucose tolerance with normal insulin release and glucagon suppression. An unequivocal hypertrophy of the muscle capillary basement membrane (1,800 +/- 148 A) was...
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In 30 ambulatory patients (14 men and 16 women), with diabetes mellitus (7 of type I and 23 of type II) of variable duration and with ages averaging 52.2 years, the degree of retinal microan giopathy was assessed along with the erythrocyte filtration rate (FR) and the percentage of glycosylated hemoglobin (HbA,). The FR was significantly (p < 0.001) lower among the diabetics (12.09 ± 2.71 JAI s...
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Chronic endothelial damage plays an important role in the development of angiopathy in diabetes mellitus (1). Since diabetic nephropathy is not determined in forty percent of patients with nonregulated type I diabetes mellitus, it is conceived that the role of hyperglycemia in angiopathy development is not very important. In addition to hyperglycemia, factors such as hypertension, hypercholeste...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1987
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf00277315